Hepatosplenomegaly

Causes of Hepatomegaly

MALIC

Malignancy(metastatic or primary)/Myelo/Lymphoproliferative disorders

Acute Alcoholic hepatitis/budd chiari can cause isolated left lobe enlargement 

Liver Abscess
Infection (viral hepatitis/autoimmune hepatitis)
Congestive Cardiac Failure, Tricuspid Regurgitation, Cirrhosis(!) 

Causes of Splenomegaly

CHINA

Cirrhosis with Portal Hypertension
Haemolytic Anaemia (thalassaemia, spherocytosis)
Infection (Infective Endocarditis, Malaria, CMV, EBV, kala azar, schistosomiasis) 

Neoplasm ( myelo/lymphoproliferative disorders)

Autoimmune (Felty's syndrome)

Causes of Hepatosplenomegaly:

CHINEI

Cirrhosis with portal hypertension (MAI WAH AV)
Haematological (thalassaemia, sickle cell, myrelo/lymphoproloferative disorders,
                            myelofibrosis)
Infection (malaria, schistosomiasis, leptospirosis, leishmaniasis, EBV, CMV)
Neoplasm ( HCC with portal hypertension)
Endocrine (acromegaly)
Infiltrative (sarcoidosis and amyloidosis)


**amyloidosis, sarcoidosis, acromegaly can cause organomegaly too!

**schistosomiasis (mansoni, japonicum, cause presinusoidal portal HTN,
                               treat with praziquantel)

Precipitating Factors of Decompensation of CLD:

HEPATICS

Haemorrhage(variceal bleed/GIT bleed)
Electrolytes Imbalances
Protein Rich Diet (more ammonia production)
Alcohol
Trauma
Infection
Constipation
Surgery